At Single Molecule Biophysics Laboratory located at GRL242, we look at biomolecules and nanoparticles one by one to understand their functions and properties. We are a young multidisciplinary research group with two primary research directions – 1) Understanding degradation of the most abundant protein in our body, i.e, collagen and 2) Bioimaging exploiting no photobleaching, no blinking, magnetically modulated emission of fluorescent nanodiamonds. Facilities include a homebuilt and multifunctional Total Internal Reflection Fluorescence (TIRF) Microscope, an innovative homebuilt Multiphoton Microscope (collaboration with Prof. Jeff Squier), complete facility for E. coli-based molecular biology, GE AKTA FPLC for protein purification, and high-end computational facility for data analyses. Please visit our research website for more information.
Our vision is to develop better imaging and analysis tools to understand important biological processes and characterize nanoparticles. Members in our group will learn independent thinking, single-molecule instrumentation, rigorous data analysis, simulation, molecular biology, and cutting edge imaging for biomedical applications. Soft skills such as grant writing, multi-tasking, presentation, and interpersonal communications will be necessary part of our collective development. Philosophy of our laboratory will be demanding with clear expectations and fairness.