Antimicrobial resistance is developing and spreading worldwide, threatening our capability to cure common infectious diseases. My research interests focus on understanding antibiotic resistance and finding alternate antimicrobial strategies against opportunistic human pathogens including Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Enterococcus faecalis/faecium. My research interests center on developing antivirulence therapy and bacteriophage therapy to treat multi drug resistant pathogen infections. My lab wants to understand the mechanism of intra/interspecies signaling systems in bacteria that involve the exchange of chemical signals (autoinducers), linking the regulation of virulence gene expression with population density. Quorum sensing system is best target to develop antivirulence drug therapy. This therapy include the use of compounds that inhibit or neutralize the effect/function of the virulence factors. Second dimension of my research is the use of viruses to kill drug resistance bacteria. Bacteriophages (phages) are described as viruses that infect bacteria and found to be effective against antibiotic resistant bacteria. Lytic phages infect a host bacterium and use host machinery to replicate leading to host cell lysis and death. Lytic phages (virulent phages) belong to the class of natural antimicrobial agents. The ultimate goal of my research is to exploit quorum sensing system and bacteriophage therapy to develop bio-detection assays, anti-virulence therapies, and effective phage therapy against multi drug resistant bacterial pathogens.